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Loss      Inherited hair loss (Alopecia Androgenetica)       Causes

Causes of Alopecia Androgenetica

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It has been determined that the main cause of inherited hair loss and baldness is hidden in the pathological effects of the male hormone testosterone biologically active metabolite dehydrotestosterone (DHT or 5α-DHT) on hair follicles located at the top of the head. When the influence of hormones activates hair root receptors  become more sensitive to the molecules of these hormones and gradually loose an ability to produce strong healthy hair, that eventually leads to balding process. Although the hormonal background is typical for all men,  the susceptibility to this form of baldness affects only some. So another important factor to cause inherited hair loss and baldness is genetic information (the code, the program), that person receives from his parents. The scientists found that in 70% of the tendency to male hair loss is inherited through the maternal line, as mother sends it to her son from her father. Another 30% are inherited from the father. Much more rarely it happens that a man with inherited hair loss is the only one in the family. So Alopecia Androgenetica is caused by a symbiosis of two factors - heredity and hormone activity. At the same time men always get to keep a "crown" of hair on the back of the head and in the temples, as hair follicles in these areas do not have receptors responsive to androgens. Therefore, in these areas is not applicable one of the main factors that causes inherited baldness - the activity of hormones, so these hair are "automatically protected" from disappearing. Sex hormones do not necessarily have a suppressive or stimulating effect on the hair follicles. Estrogens stimulate hair growth on the head, but stop the growth of hair in other parts of the body. Androgens stimulate hair growth in other parts of the body, like beard and chest, but stop the growth on the scalp. The way in which one or another hormone affects the specific hair follicle depend upon genetic characteristics of this particular follicle. Alopecia Androgenetica is quite a common cause of balding in men and hair thinning in women. With the hair loss development the principal role is given to the 5α-reductase enzymes, which convert testosterone into a DHT form. DHT shortens the active growth stage Anagen of the hair follicle and simultaneously shortens the duration of the life cycle of the hair as a result of increased hair loss. This process leads over the time to reduction in the overall number of hair follicles with an active "production" of hair shaft, as each follicle is capable to "produce" so many "generations" of hair throughout its life span. Also studies have shown that levels of androgens in affected women do not necessarily exceed the norm, so a major role in the pathogenesis of Alopecia Androgenetica is a conditional increase the hair follicle sensitivity to DHT. In men hair follicles sensitive to DHT are located on the top and on the edges of the front line of hair growth - a fairly typical picture of male baldness. For women inherited hair loss reminds Alopecia Difusa with primary thinning scattered across the top of the head. In some cases when female hormone estrogen secretion starts to reduce, and the secretion of the male hormone androgen is increasing it results in thinner hair production and formation, and, in rare cases, especially severe balding may occur. In cases of a hereditary female balding hair follicles are less prone to atrophy in specific parts of the head, thus with a correct treatment application, a satisfactory regeneration of the hair more easily achieved than in men.

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